Comprehensive analysis of transcriptomics and metabolomics to understand triptolide-induced liver injury in mice

Triptolide, a major active component of Triptergium wilfordii Hook. f, is used in the treatment of autoimmune disease. However, triptolide is associated with severe adverse reactions, especially hepatotoxicity, which limits its clinical application. To examine the underlying mechanism of triptolide-...

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Udgivet i:Toxicol Lett
Main Authors: Zhao, Jie, Xie, Cen, Wang, Kanglong, Takahashi, Shogo, Krausz, Kristopher W., Lu, Dasheng, Wang, Qiong, Luo, Yuhong, Gong, Xianqiong, Mu, Xiyan, Wang, Qiao, Su, Suwen, Gonzalez, Frank J.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7783549/
https://ncbi.nlm.nih.gov/pubmed/32835833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxlet.2020.08.007
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