A comprehensive understanding of thio TEPA metabolism in the mouse using UPLC-ESI-QTOFMS-based metabolomics

ThioTEPA, an alkylating agent with anti-tumor activity, has been used as an effective anticancer drug since the 1950s. However, a complete understanding of how its alkylating activity relates to clinical efficacy has not been achieved, the total urinary excretion of thioTEPA and its metabolites is n...

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Veröffentlicht in:Biochem Pharmacol
Hauptverfasser: Li, Fei, Patterson, Andrew D., Höfer, Constance C., Krausz, Kristopher W., Gonzalez, Frank J., Idle, Jeffrey R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6309239/
https://ncbi.nlm.nih.gov/pubmed/21300029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2011.01.024
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