Comparative Metabolism of Cyclophosphamide and Ifosfamide in the Mouse Using UPLC-ESI-QTOFMS-Based Metabolomics

Ifosfamide (IF) and cyclophosphamide (CP) are common chemotherapeutic agents. Interestingly, while the two drugs are isomers, only IF treatment is known to cause nephrotoxicity and neurotoxicity. Therefore, it was anticipated that a comparison of IF and CP drug metabolites in the mouse would reveal...

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Autori principali: Li, Fei, Patterson, Andrew D., Höfer, Constance C., Krausz, Kristopher W., Gonzalez, Frank J., Idle, Jeffrey R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2941803/
https://ncbi.nlm.nih.gov/pubmed/20541539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2010.06.002
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