Targeted Stat2 deletion in conventional dendritic cells impairs CTL responses but does not affect antibody production

STAT2 is a central component of the ISGF3 transcriptional complex downstream of type I interferon (IFN-I) signaling. The significance of in vivo IFN-I/STAT1 signals in cDCs is well-established in the generation of antitumor cytotoxic T cell (CTL) responses. However, the role of STAT2 has remained el...

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Detalles Bibliográficos
Publicado en:Oncoimmunology
Main Authors: Qiu, Connie C., Kotredes, Kevin P., Cremers, Tess, Patel, Sajan, Afanassiev, Alexandra, Slifker, Michael, Gallucci, Stefania, Gamero, Ana M.
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2020
Assuntos:
Brief Report
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7781843/
https://ncbi.nlm.nih.gov/pubmed/33457079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2020.1860477
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