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Predicting human pharmacokinetics from preclinical data: volume of distribution
This tutorial introduces background and methods to predict the human volume of distribution (V(d)) of drugs using in vitro and animal pharmacokinetic (PK) parameters. The physiologically based PK (PBPK) method is based on the familiar equation: V(d) = V(p) + ∑(T)(V(T) × k(tp)). In this equation, V(p...
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| Publicado en: | Transl Clin Pharmacol |
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| Autores principales: | , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Korean Society for Clinical Pharmacology and Therapeutics
2020
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7781809/ https://ncbi.nlm.nih.gov/pubmed/33425799 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12793/tcp.2020.28.e19 |
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