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Predicting human pharmacokinetics from preclinical data: volume of distribution
This tutorial introduces background and methods to predict the human volume of distribution (V(d)) of drugs using in vitro and animal pharmacokinetic (PK) parameters. The physiologically based PK (PBPK) method is based on the familiar equation: V(d) = V(p) + ∑(T)(V(T) × k(tp)). In this equation, V(p...
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| Publicado no: | Transl Clin Pharmacol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Korean Society for Clinical Pharmacology and Therapeutics
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7781809/ https://ncbi.nlm.nih.gov/pubmed/33425799 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12793/tcp.2020.28.e19 |
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