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Contribution of Trough Concentration Data in the Evaluation of Multiple-Dose Pharmacokinetics for Drugs with Delayed Distributional Equilibrium and Long Half-Life
PURPOSE: The performance of “trough sampling before reaching steady-state” and “serial sampling beyond the interval between steady-state” in a multiple-dose pharmacokinetic evaluation was compared. Drugs with long half-lives, following multi-compartment pharmacokinetics, and whose distribution-relat...
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| 出版年: | Drug Des Devel Ther |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Dove
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7049277/ https://ncbi.nlm.nih.gov/pubmed/32158198 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S236701 |
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