Mechanistic insights into volatile anesthetic modulation of K2P channels

K2P potassium channels are known to be modulated by volatile anesthetic (VA) drugs and play important roles in clinically relevant effects that accompany general anesthesia. Here, we utilize a photoaffinity analog of the VA isoflurane to identify a VA-binding site in the TREK1 K2P channel. The funct...

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Udgivet i:eLife
Main Authors: Wague, Aboubacar, Joseph, Thomas T, Woll, Kellie A, Bu, Weiming, Vaidya, Kiran A, Bhanu, Natarajan V, Garcia, Benjamin A, Nimigean, Crina M, Eckenhoff, Roderic G, Riegelhaupt, Paul M
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2020
Fag:
Biochemistry and Chemical Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7781597/
https://ncbi.nlm.nih.gov/pubmed/33345771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.59839
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