Discovery of TMPRSS2 inhibitors from virtual screening

The SARS-CoV-2 pandemic has prompted researchers to pivot their efforts to finding antiviral compounds and vaccines. In this study, we focused on the human host cell transmembrane protease serine 2 (TMPRSS2), which plays an important role in the viral life cycle by cleaving the spike protein to init...

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Detalhes bibliográficos
Publicado no:bioRxiv
Main Authors: Hu, Xin, Shrimp, Jonathan H., Guo, Hui, Xu, Miao, Chen, Catherine Z., Zhu, Wei, Zakharov, Alexey, Jain, Sankalp, Shinn, Paul, Simeonov, Anton, Hall, Matthew D., Shen, Min
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7781311/
https://ncbi.nlm.nih.gov/pubmed/33398276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.12.28.424413
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