Potent in vitro anti-SARS-CoV-2 activity by gallinamide A and analogues via inhibition of cathepsin L

The emergence of SARS-CoV-2 in late 2019, and the subsequent COVID-19 pandemic, has led to substantial mortality, together with mass global disruption. There is an urgent need for novel antiviral drugs for therapeutic or prophylactic application. Cathepsin L is a key host cysteine protease utilized...

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Publicado no:bioRxiv
Main Authors: Ashhurst, Anneliese S., Tang, Arthur H., Fajtová, Pavla, Yoon, Michael, Aggarwal, Anupriya, Stoye, Alexander, Larance, Mark, Beretta, Laura, Drelich, Aleksandra, Skinner, Danielle, Li, Linfeng, Meek, Thomas D., McKerrow, James H., Hook, Vivian, Tseng, Chien-Te K., Turville, Stuart, Gerwick, William H., O’Donoghue, Anthony J., Payne, Richard J.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7781308/
https://ncbi.nlm.nih.gov/pubmed/33398273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.12.23.424111
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