Potent in vitro anti-SARS-CoV-2 activity by gallinamide A and analogues via inhibition of cathepsin L

The emergence of SARS-CoV-2 in late 2019, and the subsequent COVID-19 pandemic, has led to substantial mortality, together with mass global disruption. There is an urgent need for novel antiviral drugs for therapeutic or prophylactic application. Cathepsin L is a key host cysteine protease utilized...

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Udgivet i:bioRxiv
Main Authors: Ashhurst, Anneliese S., Tang, Arthur H., Fajtová, Pavla, Yoon, Michael, Aggarwal, Anupriya, Stoye, Alexander, Larance, Mark, Beretta, Laura, Drelich, Aleksandra, Skinner, Danielle, Li, Linfeng, Meek, Thomas D., McKerrow, James H., Hook, Vivian, Tseng, Chien-Te K., Turville, Stuart, Gerwick, William H., O’Donoghue, Anthony J., Payne, Richard J.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7781308/
https://ncbi.nlm.nih.gov/pubmed/33398273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.12.23.424111
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