Potent in vitro anti-SARS-CoV-2 activity by gallinamide A and analogues via inhibition of cathepsin L

The emergence of SARS-CoV-2 in late 2019, and the subsequent COVID-19 pandemic, has led to substantial mortality, together with mass global disruption. There is an urgent need for novel antiviral drugs for therapeutic or prophylactic application. Cathepsin L is a key host cysteine protease utilized...

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Опубликовано в: :bioRxiv
Главные авторы: Ashhurst, Anneliese S., Tang, Arthur H., Fajtová, Pavla, Yoon, Michael, Aggarwal, Anupriya, Stoye, Alexander, Larance, Mark, Beretta, Laura, Drelich, Aleksandra, Skinner, Danielle, Li, Linfeng, Meek, Thomas D., McKerrow, James H., Hook, Vivian, Tseng, Chien-Te K., Turville, Stuart, Gerwick, William H., O’Donoghue, Anthony J., Payne, Richard J.
Формат: Artigo
Язык:Inglês
Опубликовано: Cold Spring Harbor Laboratory 2020
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7781308/
https://ncbi.nlm.nih.gov/pubmed/33398273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.12.23.424111
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