Choline kinase alpha impairment overcomes TRAIL resistance in ovarian cancer cells

BACKGROUND: Choline kinase-α (ChoKα/CHKA) overexpression and hyper-activation sustain altered choline metabolism conferring the cholinic phenotype to epithelial ovarian cancer (OC), the most lethal gynecological tumor. We previously proved that CHKA down-modulation reduced OC cell aggressiveness and...

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Vydáno v:J Exp Clin Cancer Res
Hlavní autoři: Rizzo, Andrea, Satta, Alessandro, Garrone, Giulia, Cavalleri, Adalberto, Napoli, Alessandra, Raspagliesi, Francesco, Figini, Mariangela, De Cecco, Loris, Iorio, Egidio, Tomassetti, Antonella, Mezzanzanica, Delia, Bagnoli, Marina
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2021
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7780408/
https://ncbi.nlm.nih.gov/pubmed/33390181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-020-01794-6
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