Simultaneous E-cadherin and PLEKHA7 expression negatively affects E-cadherin/EGFR mediated ovarian cancer cell growth

Abstract Background The disruption of E-cadherin-mediated adhesion is considered an important driver of tumor progression. Nevertheless, numerous studies have demonstrated that E-cadherin promotes growth- or invasion-related signaling, contrary to the prevailing notion. During tumor progression, epi...

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Detalhes bibliográficos
Main Authors: Katia Rea, Francesca Roggiani, Loris De Cecco, Francesco Raspagliesi, Maria Luisa Carcangiu, Joyce Nair-Menon, Marina Bagnoli, Ileana Bortolomai, Delia Mezzanzanica, Silvana Canevari, Antonis Kourtidis, Panos Z. Anastasiadis, Antonella Tomassetti
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2018-07-01
Colecção:Journal of Experimental & Clinical Cancer Research
Assuntos:
E-cadherin
Epithelial ovarian cancer
EGFR
CDK5
PLEKHA7
Acesso em linha:http://link.springer.com/article/10.1186/s13046-018-0796-1
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