A Dual-Mechanism Antibiotic Kills Gram-Negative Bacteria and Avoids Drug Resistance

The rise of antibiotic resistance and declining discovery of new antibiotics has created a global health crisis. Of particular concern, no new antibiotic classes have been approved for treating Gram-negative pathogens in decades. Here, we characterize a compound, SCH-79797, that kills both Gram-nega...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Martin, James K., Sheehan, Joseph P., Bratton, Benjamin P., Moore, Gabriel M., Mateus, André, Li, Sophia Hsin-Jung, Kim, Hahn, Rabinowitz, Joshua D., Typas, Athanasios, Savitski, Mikhail M., Wilson, Maxwell Z., Gitai, Zemer
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7780349/
https://ncbi.nlm.nih.gov/pubmed/32497502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.05.005
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