Iron chelation cancer therapy using hydrophilic block copolymers conjugated with deferoxamine

Cancer cells have high iron requirements due to their rapid growth and proliferation. Iron depletion using iron chelators has a potential in cancer treatment. Previous studies have demonstrated that deferoxamine (DFO) specifically chelates Fe(III) and exhibited antitumor activity in clinical studies...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Cancer Sci
Autori principali: Komoto, Kana, Nomoto, Takahiro, El Muttaqien, Sjaikhurrizal, Takemoto, Hiroyasu, Matsui, Makoto, Miura, Yutaka, Nishiyama, Nobuhiro
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2020
Soggetti:
Drug Discovery and Delivery
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7780030/
https://ncbi.nlm.nih.gov/pubmed/32770631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.14607
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