Engineering Tumour Cell-Binding Synthetic Polymers with Sensing Dense Transporters Associated with Aberrant Glutamine Metabolism

Increased glutamine uptake toward the elevated glutaminolysis is one of the hallmarks of tumour cells. This aberrant glutamine metabolism has recently attracted considerable attention as a diagnostic and therapeutic target. Herein, we developed glutamine-functionalized polymer to achieve a selective...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Yamada, Naoki, Honda, Yuto, Takemoto, Hiroyasu, Nomoto, Takahiro, Matsui, Makoto, Tomoda, Keishiro, Konno, Masamitsu, Ishii, Hideshi, Mori, Masaki, Nishiyama, Nobuhiro
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5519697/
https://ncbi.nlm.nih.gov/pubmed/28729677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-06438-y
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