Quantifying ADC bystander payload penetration with cellular resolution using pharmacodynamic mapping

With the recent approval of 3 new antibody drug conjugates (ADCs) for solid tumors, this class of drugs is gaining momentum for the targeted treatment of cancer. Despite significant investment, there are still fundamental issues that are incompletely understood. Three of the recently approved ADCs c...

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Bibliographic Details
Published in:Neoplasia
Main Authors: Khera, Eshita, Cilliers, Cornelius, Smith, Michael D., Ganno, Michelle L., Lai, Katharine C., Keating, Thomas A., Kopp, Anna, Nessler, Ian, Abu-Yousif, Adnan O., Thurber, Greg M.
Format: Artigo
Language:Inglês
Published: Neoplasia Press 2020
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Original article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7779838/
https://ncbi.nlm.nih.gov/pubmed/33385970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2020.12.001
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