Rational Design of Azastatin as a Potential ADC Payload with Reduced Bystander Killing

Auristatins are a class of ultrapotent microtubule inhibitors, whose growing clinical popularity in oncology is based upon their use as payloads in antibody‐drug conjugates (ADCs). The most widely utilized auristatin, MMAE, has however been shown to cause apoptosis in non‐pathological cells proximal...

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Pubblicato in:ChemMedChem
Autori principali: Hartmann, Rafael W., Fahrner, Raphael, Shevshenko, Denys, Fyrknäs, Mårten, Larsson, Rolf, Lehmann, Fredrik, Odell, Luke R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7756782/
https://ncbi.nlm.nih.gov/pubmed/33063934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202000497
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