Design, Synthesis, and Cytotoxic Evaluation of Novel Tubulysin Analogues as ADC Payloads

[Image: see text] The tubulysin class of natural products has attracted much attention from the medicinal chemistry community due to its potent cytotoxicity against a wide range of human cancer cell lines, including significant activity in multidrug-resistant carcinoma models. As a result of their p...

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Bibliografiska uppgifter
I publikationen:ACS Med Chem Lett
Huvudupphovsmän: Leverett, Carolyn A., Sukuru, Sai Chetan K., Vetelino, Beth C., Musto, Sylvia, Parris, Kevin, Pandit, Jayvardhan, Loganzo, Frank, Varghese, Alison H., Bai, Guoyun, Liu, Bin, Liu, Dingguo, Hudson, Sarah, Doppalapudi, Venkata Ramana, Stock, Joseph, O’Donnell, Christopher J., Subramanyam, Chakrapani
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Chemical Society 2016
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5108041/
https://ncbi.nlm.nih.gov/pubmed/27882198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00274
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