Improved Tumor Penetration and Single-Cell Targeting of Antibody Drug Conjugates Increases Anticancer Efficacy and Host Survival

Current antibody-drug conjugates (ADC) have made advances in engineering the antibody, linker, conjugation site, small molecule payload and drug-to-antibody ratio (DAR). However, the relationship between heterogeneous intratumoral distribution and efficacy of ADC is poorly understood. Here we compar...

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Bibliographic Details
Published in:Cancer Res
Main Authors: Cilliers, Cornelius, Menezes, Bruna, Nessler, Ian, Linderman, Jennifer, Thurber, Greg M.
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5903206/
https://ncbi.nlm.nih.gov/pubmed/29217763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-1638
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