The small molecule drug CBL0137 increases the level of DNA damage and the efficacy of radiotherapy for glioblastoma

Glioblastoma (GBM) is an incurable brain tumor with inevitable recurrence. This is in part due to a highly malignant cancer stem cell (CSC) subpopulation of tumor cells that is particularly resistant to conventional treatments, including radiotherapy. Here we show that CBL0137, a small molecule anti...

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Detalhes bibliográficos
Publicado no:Cancer Lett
Main Authors: Tallman, Miranda M, Zalenski, Abigail A, Deighen, Amanda M, Schrock, Morgan S, Mortach, Sherry, Grubb, Treg M, Kastury, Preetham S, Huntoon, Kristin, Summers, Matthew K, Venere, Monica
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7779703/
https://ncbi.nlm.nih.gov/pubmed/33253788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2020.11.027
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