STEM-26. SMALL MOLECULE DRUG CBL0137 INHIBITS THE FACT COMPLEX AND SENSITIZES GLIOBLASTOMA CANCER STEM CELLS TO RADIOTHERAPY

Glioblastoma (GBM) is a malignant brain tumor with nearly universal recurrence. GBM cancer stem cells (CSCs), a subpopulation of radio- and chemo-resistant cancer cells capable of self-renewal, contribute to the high rate of recurrence. The anti-cancer agent, CBL0137, inhibits the FACT (facilitates...

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Publicat a:Neuro Oncol
Autors principals: Tallman, Miranda, Zalenski, Abigail, Deighen, Amanda, Schrock, Morgan, Mortach, Sherry, Grubb, Treg, Kastury, Preetham, Huntoon, Kristin, Summers, Matthew, Venere, Monica
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2020
Matèries:
Cancer Stem Cells
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651431/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.843
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