Endothelial Klf2-Foxp1-TGFβ signal mediates the inhibitory effects of simvastatin on maladaptive cardiac remodeling

Aims: Pathological cardiac fibrosis and hypertrophy are common features of left ventricular remodeling that often progress to heart failure (HF). Endothelial cells (ECs) are the most abundant non-myocyte cells in adult mouse heart. Simvastatin, a strong inducer of Krüppel-like Factor 2 (Klf2) in ECs...

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Veröffentlicht in:Theranostics
Hauptverfasser: Li, Hongda, Wang, Yanfang, Liu, Jiwen, Chen, Xiaoli, Duan, Yunhao, Wang, Xiaoyu, Shen, Yajing, Kuang, Yashu, Zhuang, Tao, Tomlinson, Brain, Chan, Paul, Yu, Zuoren, Cheng, Yu, Zhang, Lin, Liu, Zhongmin, Zhang, Yuzhen, Zhao, Zhenlin, Zhang, Qi, Liu, Jie
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ivyspring International Publisher 2021
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7778601/
https://ncbi.nlm.nih.gov/pubmed/33408770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.48153
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