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A Tiered Female Ovarian Toxicity Screening Identifies Toxic Effects of Checkpoint Kinase 1 Inhibitors on Murine Growing Follicles

Ovarian toxicity (ovotoxicity) is one of the major side effects of pharmaceutical compounds for women at or before reproductive age. The current gold standard for screening of compounds’ ovotoxicity largely relies on preclinical investigations using whole animals. However, in vivo models are time-co...

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Detalhes bibliográficos
Publicado no:Toxicol Sci
Main Authors: Xu, Jingshan, Wang, Yingzheng, Kauffman, Alexandra E, Zhang, Yaqi, Li, Yang, Zhu, Jie, Maratea, Kimberly, Fabre, Kristin, Zhang, Qiang, Woodruff, Teresa K, Xiao, Shuo
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7778340/
https://ncbi.nlm.nih.gov/pubmed/32697846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfaa118
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