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The end protection problem—an unexpected twist in the tail
In this perspective, we introduce shelterin and the mechanisms of ATM activation and NHEJ at telomeres, before discussing the following questions: How are t-loops proposed to protect chromosome ends and what is the evidence for this model? Can other models explain how TRF2 mediates end protection? C...
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| 出版年: | Genes Dev |
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| 主要な著者: | , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Cold Spring Harbor Laboratory Press
2021
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7778267/ https://ncbi.nlm.nih.gov/pubmed/33361389 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.344044.120 |
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