1233. Identification of Novel Inhibitors of Clostridioides difficile Enoyl-Reductase II (FabK) by High-Throughput Virtual and Experimental Screening

BACKGROUND: Clostridioides difficile is one of only three bacteria categorized as an ‘urgent’ drug-resistant threat by the CDC. This pathogen is responsible for nearly 500,000 hospital-acquired infections and 29,000 deaths per year at a cost of nearly $4.8 billion. There is a critical need for the i...

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Publicat a:Open Forum Infect Dis
Autors principals: Wahrmund, Rebecca D, Avad, Kristiana A, Reeve, Stephanie M, Jones, Jesse A, La, Thao, Lee, Richard E, Hevener, Kirk E
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2020
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Poster Abstracts
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7777309/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofaa439.1418
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