Small-molecule inhibition of the C. difficile FAS-II enzyme, FabK, results in selective activity

Clostridioides difficile infection (CDI) is a leading cause of significant morbidity, mortality, and healthcare-related costs in the United States. After standard therapy, recurrence rates remain high and multiple recurrences are not uncommon. Causes include treatments employing broad-spectrum agent...

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Bibliographic Details
Published in:ACS Chem Biol
Main Authors: Jones, Jesse A., Prior, Allan M., Marreddy, Ravi K.R., Wahrmund, Rebecca D., Hurdle, Julian G., Sun, Dianqing, Hevener, Kirk E.
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6642025/
https://ncbi.nlm.nih.gov/pubmed/31184849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00293
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