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1296. Efficacy of Human-Simulated Exposures of Meropenem/Vaborbactam (MVB) and Meropenem (MEM) against OXA-48 β-lactamase-producing Enterobacterales in the Neutropenic Murine Thigh Infection Model

BACKGROUND: OXA-48 exhibits variable hydrolytic activity toward carbapenems, with imipenem and meropenem MICs, though increased, often reporting within the ‘susceptible’ or ‘intermediate’ ranges defined by CLSI and EUCAST. Although vaborbactam (VAB) does not enhance MEM activity against OXA-48, ~ 1/...

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Bibliografiske detaljer
Udgivet i:Open Forum Infect Dis
Main Authors: Gill, Christian M, Asempa, Tomefa E, Nicolau, David P
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7777105/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofaa439.1479
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