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Efficacy of Human-Simulated Epithelial Lining Fluid Exposure of Meropenem-Nacubactam Combination against Class A Serine β-Lactamase-Producing Enterobacteriaceae in the Neutropenic Murine Lung Infection Model

Nacubactam is a novel, broad-spectrum, β-lactamase inhibitor that is currently under development as combination therapy with meropenem. This study evaluated the efficacy of human-simulated epithelial lining fluid (ELF) exposures of meropenem, nacubactam, and the combination of meropenem and nacubact...

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Publicat a:Antimicrob Agents Chemother
Autors principals: Asempa, Tomefa E., Motos, Ana, Abdelraouf, Kamilia, Bissantz, Caterina, Zampaloni, Claudia, Nicolau, David P.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6437545/
https://ncbi.nlm.nih.gov/pubmed/30670411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02382-18
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