Exploiting MYC-induced PARPness to target genomic instability in multiple myeloma

Multiple myeloma (MM) is a hematologic malignancy strongly characterized by genomic instability, which promotes disease progression and drug resistance. Since we previously demonstrated that LIG3-dependent repair is involved in the genomic instability, drug resistance and survival of MM cells, we he...

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Vydáno v:Haematologica
Hlavní autoři: Caracciolo, Daniele, Scionti, Francesca, Juli, Giada, Altomare, Emanuela, Golino, Gaetanina, Todoerti, Katia, Grillone, Katia, Riillo, Caterina, Arbitrio, Mariamena, Iannone, Michelangelo, Morelli, Eugenio, Amodio, Nicola, Di Martino, Maria Teresa, Rossi, Marco, Neri, Antonino, Tagliaferri, Pierosandro, Tassone, Pierfrancesco
Médium: Artigo
Jazyk:Inglês
Vydáno: Fondazione Ferrata Storti 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7776341/
https://ncbi.nlm.nih.gov/pubmed/32079692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2019.240713
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