1315. No Dose Adjustment of Metformin with Fostemsavir Coadministration Based on Mechanistic Static and Physiologically Based Pharmacokinetic Models

BACKGROUND: Fostemsavir (FTR) is an oral prodrug of the first-in-class attachment inhibitor temsavir (TMR) which is being evaluated in patients with multidrug resistant HIV-1 infection. In vitro studies indicated that TMR and its 2 major metabolites are inhibitors of organic cation transporters (OCT...

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Publicado en:Open Forum Infect Dis
Autores principales: Nguyen, Dung N, Miao, Xiusheng, Magee, Mindy, Tai, Guoying, Gorycki, Peter D, Moore, Katy P
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2020
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Poster Abstracts
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7776151/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofaa439.1497
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