Pharmacokinetics of Temsavir, the Active Moiety of the Prodrug Fostemsavir, in Subjects with Hepatic Impairment

BACKGROUND: Fostemsavir (FTR) is a prodrug of temsavir (TMR), a first-in-class attachment inhibitor that binds directly to HIV-1 gp120, preventing initial viral attachment and entry into host CD4+ T cells. TMR is primarily metabolized via hydrolytic and oxidative pathways; impaired hepatic function...

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Detalhes bibliográficos
Publicado no:Open Forum Infect Dis
Main Authors: Sevinsky, Heather, Magee, Mindy, Ackerman, Peter, Adamczyk, Robert, Karkas, Jennifer, Lubin, Susan, Ravindran, Palanikumar, Llamoso, Cyril, Eley, Timothy, Moore, Katy
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5630802/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofx163.1086
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