Absence of NLRP3 Inflammasome in Hematopoietic Cells Reduces Adverse Remodeling After Experimental Myocardial Infarction

An inflammatory response is required for tissue healing after a myocardial infarction (MI), but the process must be balanced to prevent maladaptive remodeling. This study shows that improved survival and cardiac function following MI, in mice deficient for the NLRP3 inflammasome, can be recapitulate...

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Bibliographic Details
Published in:JACC Basic Transl Sci
Main Authors: Louwe, Mieke C., Olsen, Maria B., Kaasbøll, Ole J., Yang, Kuan, Fosshaug, Linn E., Alfsnes, Katrine, Øgaard, Jonas D.S., Rashidi, Azita, Skulberg, Vidar M., Yang, Mingyi, de Miranda Fonseca, Davi, Sharma, Animesh, Aronsen, Jan Magnus, Schrumpf, Elisabeth, Ahmed, Muhammad Shakil, Dahl, Christen Peder, Nyman, Tuula A., Ueland, Thor, Melum, Espen, Halvorsen, Bente E., Bjørås, Magnar, Attramadal, Håvard, Sjaastad, Ivar, Aukrust, Pål, Yndestad, Arne
Format: Artigo
Language:Inglês
Published: Elsevier 2020
Subjects:
Preclinical Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7775960/
https://ncbi.nlm.nih.gov/pubmed/33426377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacbts.2020.09.013
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