Sustained Toll-Like Receptor 9 Activation Promotes Systemic and Cardiac Inflammation, and Aggravates Diastolic Heart Failure in SERCA2a KO Mice

AIM: Cardiac inflammation is important in the pathogenesis of heart failure. However, the consequence of systemic inflammation on concomitant established heart failure, and in particular diastolic heart failure, is less explored. Here we investigated the impact of systemic inflammation, caused by su...

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Udgivet i:PLoS One
Main Authors: Dhondup, Yangchen, Sjaastad, Ivar, Scott, Helge, Sandanger, Øystein, Zhang, Lili, Haugstad, Solveig Bjærum, Aronsen, Jan Magnus, Ranheim, Trine, Holmen, Sigve Dhondup, Alfsnes, Katrine, Ahmed, Muhammad Shakil, Attramadal, Håvard, Gullestad, Lars, Aukrust, Pål, Christensen, Geir, Yndestad, Arne, Vinge, Leif Erik
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4604200/
https://ncbi.nlm.nih.gov/pubmed/26461521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0139715
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