Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM

The recent outbreaks of SARS-CoV-2 pose a global health emergency. The SARS-CoV-2 trimeric spike (S) glycoprotein interacts with the human ACE2 receptor to mediate viral entry into host cells. We report the cryo-EM structures of a tightly closed SARS-CoV-2 S trimer with packed fusion peptide and an...

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Publicado en:Sci Adv
Autores principales: Xu, Cong, Wang, Yanxing, Liu, Caixuan, Zhang, Chao, Han, Wenyu, Hong, Xiaoyu, Wang, Yifan, Hong, Qin, Wang, Shutian, Zhao, Qiaoyu, Wang, Yalei, Yang, Yong, Chen, Kaijian, Zheng, Wei, Kong, Liangliang, Wang, Fangfang, Zuo, Qinyu, Huang, Zhong, Cong, Yao
Formato: Artigo
Lenguaje:Inglês
Publicado: American Association for the Advancement of Science 2021
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Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7775788/
https://ncbi.nlm.nih.gov/pubmed/33277323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abe5575
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