Trisomy 21–induced dysregulation of microglial homeostasis in Alzheimer’s brains is mediated by USP25

Down syndrome (DS), caused by trisomy of chromosome 21, is the most significant risk factor for early-onset Alzheimer’s disease (AD); however, underlying mechanisms linking DS and AD remain unclear. Here, we show that triplication of homologous chromosome 21 genes aggravates neuroinflammation in com...

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Veröffentlicht in:Sci Adv
Hauptverfasser: Zheng, Qiuyang, Li, Guilin, Wang, Shihua, Zhou, Ying, Liu, Ke, Gao, Yue, Zhou, Yulin, Zheng, Liangkai, Zhu, Lin, Deng, Qingfang, Wu, Meiling, Di, Anjie, Zhang, Lishan, Zhao, Yingjun, Zhang, Hongfeng, Sun, Hao, Dong, Chen, Xu, Huaxi, Wang, Xin
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Association for the Advancement of Science 2021
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7775784/
https://ncbi.nlm.nih.gov/pubmed/33523861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abe1340
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