Inhibition of the NLRP3 inflammasome prevents ovarian aging

Inflammation is a hallmark of aging and is negatively affecting female fertility. In this study, we evaluate the role of the NLRP3 inflammasome in ovarian aging and female fertility. Age-dependent increased expression of NLRP3 in the ovary was observed in WT mice during reproductive aging. High expr...

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Veröffentlicht in:Sci Adv
Hauptverfasser: Navarro-Pando, José M., Alcocer-Gómez, Elísabet, Castejón-Vega, Beatriz, Navarro-Villarán, Elena, Condés-Hervás, Mónica, Mundi-Roldan, María, Muntané, Jordi, Pérez-Pulido, Antonio J., Bullon, Pedro, Wang, Chun, Hoffman, Hal M., Sanz, Alberto, Mbalaviele, Gabriel, Ryffel, Bernhard, Cordero, Mario D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Association for the Advancement of Science 2021
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7775749/
https://ncbi.nlm.nih.gov/pubmed/33523841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abc7409
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