TrkB deubiquitylation by USP8 regulates receptor levels and BDNF-dependent neuronal differentiation

Ubiquitylation of receptor tyrosine kinases (RTKs) regulates both the levels and functions of these receptors. The neurotrophin receptor TrkB (also known as NTRK2), a RTK, is ubiquitylated upon activation by brain-derived neurotrophic factor (BDNF) binding. Although TrkB ubiquitylation has been demo...

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Detaylı Bibliyografya
Yayımlandı:J Cell Sci
Asıl Yazarlar: Martín-Rodríguez, Carlos, Song, Minseok, Anta, Begoña, González-Calvo, Francisco J., Deogracias, Rubén, Jing, Deqiang, Lee, Francis S., Arevalo, Juan Carlos
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Company of Biologists Ltd 2020
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7774901/
https://ncbi.nlm.nih.gov/pubmed/33288548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.247841
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