Alterations of DNA damage response genes correlate with response and overall survival in anti‐PD‐1/PD‐L1‐treated advanced urothelial cancer

DNA damage response (DDR) gene alterations in cancer are associated with a higher tumor mutational burden (TMB) and may impact clinical outcomes of urothelial cancer (UC). Here, we explore the prognostic role of DDR alterations in advanced UC treated with anti‐PD‐1/PD‐L1 agents. The study included 5...

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Udgivet i:Cancer Med
Main Authors: Joshi, Monika, Grivas, Petros, Mortazavi, Amir, Monk, Paul, Clinton, Steven K., Sue‐Ann Woo, Michele, Holder, Sheldon L., Drabick, Joseph J., Yin, Ming
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
Fag:
Clinical Cancer Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7774722/
https://ncbi.nlm.nih.gov/pubmed/33098265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.3552
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