Serine 165 phosphorylation of SHARPIN regulates the activation of NF-κB

The adaptor SHARPIN composes, together with the E3 ligases HOIP and HOIL1, the linear ubiquitin chain assembly complex (LUBAC). This enzymatic complex catalyzes and stamps atypical linear ubiquitin chains onto substrates to modify their fate and has been linked to the regulation of the NF-κB pathway...

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Gepubliceerd in:iScience
Hoofdauteurs: Thys, An, Trillet, Kilian, Rosińska, Sara, Gayraud, Audrey, Douanne, Tiphaine, Danger, Yannic, Renaud, Clotilde C.N., Antigny, Luc, Lavigne, Régis, Pineau, Charles, Com, Emmanuelle, Vérité, Franck, Gavard, Julie, Bidère, Nicolas
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7773595/
https://ncbi.nlm.nih.gov/pubmed/33392484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101939
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