Tissue-resident PSGL1(lo)CD4(+) T cells promote B cell differentiation and chronic graft-versus-host disease–associated autoimmunity

CD4(+) T cell interactions with B cells play a critical role in the pathogenesis of systemic autoimmune diseases such as systemic lupus and chronic graft-versus-host disease (cGVHD). Extrafollicular CD44(hi)CD62L(lo)PSGL1(lo)CD4(+) T cells (PSGL1(lo)CD4(+) T cells) are associated with the pathogenes...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Kong, Xiaohui, Zeng, Deye, Wu, Xiwei, Wang, Bixin, Yang, Shijie, Song, Qingxiao, Zhu, Yongping, Salas, Martha, Qin, Hanjun, Nasri, Ubaydah, Haas, Karen M., Riggs, Arthur D., Nakamura, Ryotaro, Martin, Paul J., Huang, Aimin, Zeng, Defu
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2021
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7773409/
https://ncbi.nlm.nih.gov/pubmed/32931481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI135468
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