Reversal of autoimmunity by mixed chimerism enables reactivation of β cells and transdifferentiation of α cells in diabetic NOD mice

Type 1 diabetes (T1D) results from the autoimmune destruction of β cells, so cure of firmly established T1D requires both reversal of autoimmunity and restoration of β cells. It is known that β cell regeneration in nonautoimmune diabetic mice can come from differentiation of progenitors and/or trans...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Tang, Shanshan, Zhang, Mingfeng, Zeng, Samuel, Huang, Yaxun, Qin, Melissa, Nasri, Ubaydah, Santamaria, Pere, Riggs, Arthur D., Jin, Liang, Zeng, Defu
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2020
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7733788/
https://ncbi.nlm.nih.gov/pubmed/33229527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2012389117
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