Defective lysosome reformation during autophagy causes skeletal muscle disease

The regulation of autophagy-dependent lysosome homeostasis in vivo is unclear. We showed that the inositol polyphosphate 5-phosphatase INPP5K regulates autophagic lysosome reformation (ALR), a lysosome recycling pathway, in muscle. INPP5K hydrolyzes phosphatidylinositol-4,5-bisphosphate [PI(4,5)P(2)...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:J Clin Invest
Autors principals: McGrath, Meagan J., Eramo, Matthew J., Gurung, Rajendra, Sriratana, Absorn, Gehrig, Stefan M., Lynch, Gordon S., Lourdes, Sonia Raveena, Koentgen, Frank, Feeney, Sandra J., Lazarou, Michael, McLean, Catriona A., Mitchell, Christina A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2021
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7773396/
https://ncbi.nlm.nih.gov/pubmed/33119550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI135124
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars