Macrophage-derived netrin-1 drives adrenergic nerve–associated lung fibrosis

Fibrosis is a macrophage-driven process of uncontrolled extracellular matrix accumulation. Neuronal guidance proteins such as netrin-1 promote inflammatory scarring. We found that macrophage-derived netrin-1 stimulates fibrosis through its neuronal guidance functions. In mice, fibrosis due to inhale...

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Podrobná bibliografie
Vydáno v:J Clin Invest
Hlavní autoři: Gao, Ruijuan, Peng, Xueyan, Perry, Carrighan, Sun, Huanxing, Ntokou, Aglaia, Ryu, Changwan, Gomez, Jose L., Reeves, Benjamin C., Walia, Anjali, Kaminski, Naftali, Neumark, Nir, Ishikawa, Genta, Black, Katharine E., Hariri, Lida P., Moore, Meagan W., Gulati, Mridu, Homer, Robert J., Greif, Daniel M., Eltzschig, Holger K., Herzog, Erica L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2021
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7773383/
https://ncbi.nlm.nih.gov/pubmed/33393489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI136542
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