Macrophage-derived netrin-1 drives adrenergic nerve–associated lung fibrosis

Fibrosis is a macrophage-driven process of uncontrolled extracellular matrix accumulation. Neuronal guidance proteins such as netrin-1 promote inflammatory scarring. We found that macrophage-derived netrin-1 stimulates fibrosis through its neuronal guidance functions. In mice, fibrosis due to inhale...

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Udgivet i:J Clin Invest
Main Authors: Gao, Ruijuan, Peng, Xueyan, Perry, Carrighan, Sun, Huanxing, Ntokou, Aglaia, Ryu, Changwan, Gomez, Jose L., Reeves, Benjamin C., Walia, Anjali, Kaminski, Naftali, Neumark, Nir, Ishikawa, Genta, Black, Katharine E., Hariri, Lida P., Moore, Meagan W., Gulati, Mridu, Homer, Robert J., Greif, Daniel M., Eltzschig, Holger K., Herzog, Erica L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7773383/
https://ncbi.nlm.nih.gov/pubmed/33393489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI136542
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