Mitigating oxygen stress enhances aged mouse hematopoietic stem cell numbers and function

Bone marrow (BM) hematopoietic stem cells (HSCs) become dysfunctional during aging (i.e., they are increased in number but have an overall reduction in long-term repopulation potential and increased myeloid differentiation) compared with young HSCs, suggesting limited use of old donor BM cells for h...

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Bibliografske podrobnosti
izdano v:J Clin Invest
Main Authors: Capitano, Maegan L., Mohamad, Safa F., Cooper, Scott, Guo, Bin, Huang, Xinxin, Gunawan, Andrea M., Sampson, Carol, Ropa, James, Srour, Edward F., Orschell, Christie M., Broxmeyer, Hal E.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2021
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7773345/
https://ncbi.nlm.nih.gov/pubmed/33393491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI140177
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