Mitigating oxygen stress enhances aged mouse hematopoietic stem cell numbers and function

Bone marrow (BM) hematopoietic stem cells (HSCs) become dysfunctional during aging (i.e., they are increased in number but have an overall reduction in long-term repopulation potential and increased myeloid differentiation) compared with young HSCs, suggesting limited use of old donor BM cells for h...

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Vydáno v:J Clin Invest
Hlavní autoři: Capitano, Maegan L., Mohamad, Safa F., Cooper, Scott, Guo, Bin, Huang, Xinxin, Gunawan, Andrea M., Sampson, Carol, Ropa, James, Srour, Edward F., Orschell, Christie M., Broxmeyer, Hal E.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2021
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7773345/
https://ncbi.nlm.nih.gov/pubmed/33393491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI140177
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