Mitigating oxygen stress enhances aged mouse hematopoietic stem cell numbers and function

Bone marrow (BM) hematopoietic stem cells (HSCs) become dysfunctional during aging (i.e., they are increased in number but have an overall reduction in long-term repopulation potential and increased myeloid differentiation) compared with young HSCs, suggesting limited use of old donor BM cells for h...

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Detaylı Bibliyografya
Yayımlandı:J Clin Invest
Asıl Yazarlar: Capitano, Maegan L., Mohamad, Safa F., Cooper, Scott, Guo, Bin, Huang, Xinxin, Gunawan, Andrea M., Sampson, Carol, Ropa, James, Srour, Edward F., Orschell, Christie M., Broxmeyer, Hal E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2021
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7773345/
https://ncbi.nlm.nih.gov/pubmed/33393491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI140177
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