Intrathecal catheter implantation decreases cerebrospinal fluid dynamics in cynomolgus monkeys

A detailed understanding of the CSF dynamics is needed for design and optimization of intrathecal drug delivery devices, drugs, and protocols. Preclinical research using large-animal models is important to help define drug pharmacokinetics-pharmacodynamics and safety. In this study, we investigated...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Khani, Mohammadreza, Fu, Audrey Q., Pluid, Joshua, Gibbs, Christina P., Oshinski, John N., Xing, Tao, Stewart, Gregory R., Zeller, Jillynne R., Martin, Bryn A.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2020
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7773283/
https://ncbi.nlm.nih.gov/pubmed/33378399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0244090
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