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Integrating biokinetics and in vitro studies to evaluate developmental neurotoxicity induced by chlorpyrifos in human iPSC-derived neural stem cells undergoing differentiation towards neuronal and glial cells

For some complex toxicological endpoints, chemical safety assessment has conventionally relied on animal testing. Apart from the ethical issues, also scientific considerations have been raised concerning the traditional approach, highlighting the importance for considering real life exposure scenari...

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Detalhes bibliográficos
Publicado no:Reprod Toxicol
Main Authors: Di Consiglio, Emma, Pistollato, Francesca, Mendoza-De Gyves, Emilio, Bal-Price, Anna, Testai, Emanuela
Formato: Artigo
Idioma:Inglês
Publicado em: Pergamon In Cooperation With The Reproductive Toxicology Center 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7772889/
https://ncbi.nlm.nih.gov/pubmed/33011216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.reprotox.2020.09.010
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