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Identification of cGAS as an innate immune sensor of extracellular bacterium Pseudomonas aeruginosa
Cyclic GMP-AMP synthase (cGAS) is reported essential for detecting intracellular bacteria. However, it remains to be determined whether and how cGAS is involved in extracellular bacterial infection. Here, we report that cGAS is essential for mediating type I interferon (IFN) production in infection...
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| Pubblicato in: | iScience |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Elsevier
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7772558/ https://ncbi.nlm.nih.gov/pubmed/33385121 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101928 |
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