A New Framework to Implement Model-Informed Dosing in Clinical Guidelines: Piperacillin and Amikacin as Proof of Concept

Background: Modeling and simulation is increasingly used to study pediatric pharmacokinetics, but clinical implementation of age-appropriate doses lags behind. Therefore, we aimed to develop model-informed doses using published pharmacokinetic data and a decision framework to adjust dosing guideline...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Hartman, Stan J. F., Swaving, Joost G. E., van Beek, Stijn W., van Groen, Bianca D., de Hoop, Marika, van der Zanden, Tjitske M., ter Heine, Rob, de Wildt, Saskia N.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7772249/
https://ncbi.nlm.nih.gov/pubmed/33390970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.592204
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